Description

Aseptic Blow-Fill-Seal System

BFS is short for the Blow-Fill-Seal technique. It has been developed so that formation for the container, filling and sealing takes place in a single machine under a controlled environment that enables the packaging of a pharmaceutical liquid in an aseptic manner. As the container is made, filled and sealed within a single machine and protected by sterile laminar air, the chance of contamination is very remote. Moreover, during the whole cycle, all process media like solution, air & etc. are previously sterile-filtered and open containers remain exposed to the cleanroom air for less than 1.5 seconds. The Blow-Fill-Seal technology becomes the process of choice when contamination of particles and microbial are primary concerns in production.

Blow-Fill-Seal Technique

The Blow Fill Seal Technique has been developed so that formation of the container, filling and  sealing takes place in a single machine under a controlled environment that enables the packaging  of a pharmaceutical liquid in an aseptic manner. The following picture show the major phases in the integrated packaging of parenteral solutions using the AFP® system. Aseptic packaging process As the container is made, filled and sealed within a single machine and the process is protected using a sterile air shower and additionally, all process media (solution, air etc.) are sterile filtered, the

chance of contamination is very remote. Adding to the fact that during the whole cycle, open containers remain exposed to the clean room air for less than 1.5 seconds, the Blow-Fill-Seal technology becomes the process of choice where contamination of particle matter and microbial contamination is a primary concern.

Extrusion

With high speed screw rod, thermoplastic material is continuously extruded in a tubular shape. Aseptic air blows to the plastic tube parison, and the parison goes through the forming mould.

 

 

 

 

 

 

 

 

Blowing

The main forming mould closes and the bottom of plastic parison is sealed. The cutting knife cut the parison.The top of plastic parison is located by the open protecting clamp.Aseptic air continuously protects the open tube parison.The plastic material is formed into containers as determined by the design of the mould by vacuum and/or aseptic compressed air

Filling

The containers are filled immediately and the air in the container is displaced .In the filling process, the containers are
protected by the aseptic air as Grade A.

Sealing

At the same time, the tube prison between top of plastic mould and the open protecting clamp remains semi-melting condition, and then the sealed mould closes and forms the top of the container and keeps the container sealed.

Out feeding

After sealed, the mould is opened, and the containers are totally formed, filled, sealed and is ready to outfeed. Then the machine starts the next cycle.

Advantages

1. Our products are certificated by the most prestigious national and international institutes.
2. We have established long-term business relations with many customers and some of our overseas customers have appointed us to be their purchase agency in China.
3. We will supply you with a proposal as to your specific requirement, and each machine is customized to satisfy the customer’s needs well.